葡萄糖酸锌（Zinc Gluconate）：血液透析患者的潜在必要补充剂

血液透析患者存在以下一些问题：血清白蛋白水平下降、睡眠质量差和生活质量低下。由于血液透析期间血清白蛋白排泄增加，血液透析患者的血清白蛋白通常比健康个体少。此外，血液透析患者的高度炎症和营养不良会导致血清白蛋白合成减少。在改善血清白蛋白水平上，锌元素对白蛋白合成过程至关重要。研究表明，补充锌可促进蛋白质合成相关酶的活性，在严重锌缺乏人群中，补充葡萄糖酸锌（Zinc Gluconate）能显著提升白蛋白水平；同时，在糖尿病患者中，锌元素还能减少血清白蛋白流失，这为血液透析患者提高血清白蛋白水平带来希望。此外，锌状态与炎症反应密切相关。轻度锌缺乏会促使单核细胞生成白细胞介素 1β（IL-1β）等促炎标志物增加，而补充锌可调节炎症反应，降低 C 反应蛋白（CRP）等炎症指标水平，减轻患者体内炎症状态，间接为血清白蛋白合成创造良好环境。且葡萄糖酸锌（Zinc Gluconate）这种类型的锌补充剂胃肠道吸收较好，消化不良事件较少，是血液透析患者的潜在必要补充剂。

葡萄糖酸锌（Zinc Gluconate）：血液透析患者的潜在必要补充剂

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Zinc Gluconate: A Potential Essential Supplement for Hemodialysis Patients

Hemodialysis patients face several problems, such as decreased serum albumin levels, poor sleep quality, and low quality of life. Due to increased excretion of serum albumin during hemodialysis, the serum albumin level in hemodialysis patients is usually lower than that in healthy individuals. In addition, the high - level inflammation and malnutrition in hemodialysis patients lead to a reduction in serum albumin synthesis.In terms of improving serum albumin levels, zinc is crucial for the albumin synthesis process. Studies have shown that zinc supplementation can enhance the activity of enzymes related to protein synthesis. In people with severe zinc deficiency, supplementation with Zinc Gluconate can significantly increase albumin levels. Meanwhile, in diabetic patients, zinc can reduce the loss of serum albumin, which brings hope for hemodialysis patients to increase their serum albumin levels. Moreover, the zinc status is closely related to the inflammatory response. Mild zinc deficiency can prompt monocytes to increase the production of pro - inflammatory markers such as interleukin 1 beta (IL - 1β), while zinc supplementation can regulate the inflammatory response, reduce the levels of inflammatory indicators such as C - reactive protein (CRP), alleviate the inflammatory state in patients, and indirectly create a favorable environment for serum albumin synthesis.

Zinc supplements in the form of Zinc Gluconate are well - absorbed by the gastrointestinal tract and are associated with fewer indigestion events, making them a potential essential supplement for hemodialysis patients.

Zinc Gluconate: A Potential Essential Supplement for Hemodialysis Patients

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